Author	Year	Sample size (F/M)	Gender (male vs. female)	Smoking status (smoking vs. non-smoking)	ECOG PS (1–2 vs. 0)	History of another cancer (yes vs. no)	Brain metastasis (yes vs. no)	Liver metastasis (yes vs. no)	Prior systemic therapy (yes vs. no)
Umang Swami (11)	2020	59/110	0.98 [0.60, 1.59] p = 0.93	1.25 [0.66, 2.36] p = 0.79	NA	0.57 [0.18, 1.82] p = 0.35	3.41 [2.13, 5.46] p < 0.01	2.06 [1.22, 3.48] p < 0.01	1.14 [0.72, 1.82] p = 0.57
A. Cortellini (12)	2021	115/187	1.19 [0.83, 1.69] p = 0.3273	1.81 [0.86, 3.79] p = 0.1128	3.01 [1.88, 4.83] p < 0.0001	NA	1.30 [0.88, 1.91] p = 0.1856	1.46 [0.93, 2.30] p = 0.0974	NA
Anne Schett (14)	2019	87/131	1.83 [0.85, 3.91] p = 0.12	0.44 [0.15, 1.28] p = 0.13	0.58 [0.29, 1.17] p = 0.13	2.52 [1.14, 5.58] p = 0.02	1.30 [0.60, 2.83] p = 0.51	NA	NA
Chirayu Mohindroo (15)	2020	147/195	0.82 [0.64, 1.06] p = 0.13	NA	NA	NA	NA	NA	NA
L. Derosa-1 (17)	2018	41/80	NA	NA	NA	2.4 [1.2, 4.6] p < 0.01	NA	NA	NA
L. Derosa-2 (17)	2018	41/80	NA	1.2 [0.7, 1.9] p = 0.55	3.6 [1.9, 6.5] p < 0.01	1.4 [0.8, 1.6] p = 0.57	NA	NA	1.9 [1.3, 2.9] p < 0.01
NADINA TINSLEY (18)	2019	110/181	1.126 p = 0.495	NA	1.647 p = 0.01	1.526 p = 0.018	1.373 p = 0.263	NA	0.950 p = 0.788
Hyunho Kim (19)	2019	66/168	NA	NA	2.46 [1.29, 4.71] p = 0.006	0.956 [0.59, 1.54] p = 0.855	1.008 [0.55, 1.84] p = 0.979	NA	NA