Author	Year	Sample size (F/M)	Gender (male vs. female)	Smoking status (smoking vs. non-smoking)	ECOG PS (1–2 vs. 0)	History of another cancer (yes vs. no)	Brain metastasis (yes vs. no)	Liver metastasis (yes vs. no)	BRAF mutation (yes vs. no)
Umang Swami (11)	2020	59/110	1.09 [0.75, 1.60] p = 0.65	1.03 [0.60, 1.77] p = 0.80	NA	0.90 [0.42, 1.93] p = 0.78	1.84 [1.22, 2.76] p < 0.01	1.47 [0.91, 2.36] p = 0.11	0.84 [0.58, 1.22] p = 0.36
A. Cortellini (12)	2021	115/187	1.03 [0.77, 1.38] p = 0.7994	1.27 [0.70, 2.30] p = 0.4139	2.06 [1.35, 3.12] p = 0.0007	NA	1.04 [0.75, 1.44] p = 0.7785	1.16 [0.78, 1.74] p = 0.0454	NA
KOSUKE UEDA (13)	2019	24/7	1.941 [0.67, 5.12] p = 0.2106	NA	NA	NA	NA	0.842 [0.19, 2.58] p = 0.7830	NA
Anne Schett (14)	2019	87/131	1.06 [0.62, 1.82] p = 0.82	0.42 [0.17, 1.03] p = 0.06	0.90 [0.51, 1.58] p = 0.70	1.66 [0.86, 3.20] p = 0.13	1.04 [0.75, 1.44] p = 0.29	NA	NA
Chirayu Mohindroo (15)	2020	147/195	0.83 [0.65, 1.07] p = 0.15	NA	NA	NA	NA	NA	NA
Arielle Elkrief (16)	2019	34/40	0.95 [0.50, 179] p = 0.87	NA	0.42 [0.24, 0.77] p = 0.01	NA	NA	NA	0.94 [0.38, 2.35] p = 0.90
L. Derosa-1 (17)	2018	41/80	NA	NA	NA	2.1 [1.3, 3.3] p < 0.01	NA	NA	NA
L. Derosa-2 (17)	2018	41/80	NA	0.7 [0.5, 1.0] p = 0.04	1.7 [1.2, 2.4] p < 0.01	1.1 [0.8, 1.5] p = 0.92	NA	NA	NA
NADINA TINSLEY (18)	2019	110/181	1.3 p = 0.07	NA	1.419 p = 0.028	1.42 p = 0.016	1.276 p = 0.233	NA	NA
Hyunho Kim (19)	2019	66/168	NA	NA	2.316 [1.128, 4.187] p = 0.005	1.064 [0.70, 1.61] p = 0.768	0.83 [0.48, 1.42] p = 0.502	NA	NA