Table 2.

Independent clinical, radiological, and pathological factors associated with overall survival of patients with glioblastomas.

	All Glioblastomas		Histological Glioblastomas		Molecular Glioblastomas
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Age at diagnosis	1.017 (1.004, 1.030)	0.010	1.015 (1.000, 1.030)	0.045
Male	1.482 (1.045, 2.103)	0.027			3.930 (1.574, 9.808)	0.003
Preoperative motor dysfunction					4.167 (1.523, 11.398)	0.005
Insular lobe/thalamus/callosum involvement	2.073 (1.352, 3.179)	0.001	2.286 (1.406, 3.717)	0.001
Tumor related to the functional region	1.877 (1.296, 2.719)	0.001	1.567 (1.050, 2.339)	0.028	4.678 (1.500, 14.591)	0.008
Extent of resection
Biopsy	reference		reference		reference
Subtotal resection	0.390 (0.232, 0.655)	<0.001	0.417 (0.235, 0.863)	0.016	0.175 (0.055, 0.563)	0.003
Gross total resection	0.348 (0.226, 0.535)	<0.001	0.374 (0.217, 0.636)	<0.001	0.108 (0.033, 0.349)	<0.001
Postoperative treatment
Without standardized Stupp protocol	reference		reference
Stupp protocol w/o additional therapies	0.577 (0.373, 0.891)	0.013	0.450 (0.272, 0.746)	0.002
Ki-67 index					1.028 (1.002, 1.054)	0.036
p53 alteration					8.970 (2.353, 34.199)	0.001
MGMT promoter methylation	0.596 (0.359, 0.989)	0.045
CDK4 alteration	2.366 (1.280, 4.373)	0.006			5.964 (1.836, 19.370)	0.003
CDK6 alteration	25.813 (1.645, 405.012)	0.021	15026 (171.311, 1.3x10^6)	<0.001
CIC alteration			6.112 (1.209, 30.901)	0.029
FGFR3 alteration					4.265 (1.230, 14.786)	0.022
KMT5B alteration	3.452 (1.294, 9.207)	0.013			21.293 (3.447, 131.521)	0.001
MYB alteration			415.989 (17.899, 9668.181)	<0.001

The bold values in the "P value" column indicated significant P values (<0.05).