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. 2023 Jul 6;14:1211271. doi: 10.3389/fmicb.2023.1211271

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Copyright © 2023 Huang, Hao, Wang, Zhou and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Main Causes of Ulcerative Colitis. UC may occur as a result of the interaction of the imbalance of gut microbiota, immune disorders, genetic susceptibility, and other factors with external stimuli. The loss of beneficial intestinal flora and the increase of harmful flora disrupt the intestinal environment. The decrease of intestinal epithelial intercellular tight junction proteins as well as mucins also causes damage to the intestinal barrier. Psychological factors and poor lifestyle habits are also risk factors for the development of UC. Various harmful factors trigger intestinal immune disorders and release large amounts of pro-inflammatory factors, causing intestinal inflammation.