TABLE 6.

Summary of recent heart-on-chip studies with (bio-)chemical monitoring.

Article	Cell type	Oxygen	pH	Biosensing		Perfusion
Schneider et al. (2022)	3D hiPSC-CMs, primary human dermal fibroblasts	Luminescence, fiberoptic			in situ	x
Zhang et al. (2017)	3D Human primary hepatocytes, human iPSC-CMs	Luminescence	optical absorption	Electrochemical immu-nosensor: CK-MB	in-line	x
Tanumihardja et al. (2021)	2D hPSC-CM s	RuOx electrode, potentiometric	RuOx electrode, chronoamperometric		in situ	static
Lee et al. (2021)	3D iPSC-CMs, brest cancer tissues	-	-	electrochemical immuno-aptasensing; Troponin T, CK-MB, HER-2, IL-8	on-line	x
Shin et al. (2016)	ESC-CMs			Electrochemical immunoaptasensing; CK-MB	off-line	x
Kolanowski et al. (2020)	hiPSC-CMs	Luminescence, fiberoptic			in-line	x
Häkli et al. (2022b)	hiPSC-CMs monolayer	Luminescence			in situ	static
Häkli et al. (2021)	hiPSC-CMs monolayer	Luminescence			in situ	static