FIGURE 7.

A comparison of the fold change of genes across brain regions in AD. (A) Faceted plot is shown in which each panel represents a gene. Along the x-axis are brain regions and the fold change of the gene in patients with AD is expressed by the height of the bar. Each panel is colored into green and red regions to make it clear which direction the bars face, and, in turn, the corresponding fold change of the gene. The upper portion of each panel is colored red; bars which stretch into this region represent genes with a positive log fold change in AD. The lower portion of each panel is colored green; bars which stretch into this region represent genes with a negative log fold change in AD. Each tissue is also given its own color; some genes were not expressed in some tissues or not associated with a significant log fold change and, as a consequence, not every panel contains data for every tissue. Largely the patterns of log fold change remain consistent across tissues but there are exceptions in which genes show a different pattern of expression in the parietal lobe compared to other tissues. (B–F) Variance-stabilizing transformed counts of top 5 most-associated genes and HERVs as calculated by Arboreto.