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. 2023 Jul 6;14:1063408. doi: 10.3389/fneur.2023.1063408

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Copyright © 2023 Chen, Dadario, Cook, Sun, Wang, Li, Hu, Zhang and Sughrue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysfunctional connectivity between patient clusters. Connectivity anomalies are demonstrated on a heat map between patients according to clustering analyses for the (1) National Institutes of Health Stroke Scale (NIHSS) (top left), (2) Barthel Index (BI) (top right), (3) Fugl-Meyer Assessment (FMA) (bottom left), and (4) Wolf Motor Function Test (WMFT) (bottom right). Hyperconnected parcels are demonstrated in red, with a higher mean number of hyperconnections in dark red and a lower mean number of hyperconnections in light red. Hypoconnected parcels are demonstrated in blue, with a higher mean number of hypoconnections in dark blue and a lower mean number of hypoconnections in light blue. Each brain region, ipsilateral or contralateral to the stroke site, is labeled on the y-axis. Individual patient clusters are on the x-axis. These outcomes are further demonstrated in the Supplementary material.