Table 4.

Computational performance of the LDA-based method

Cells number	Genes number	Topics (PFs) number	Threads number	Avg. memory (GB)	Avg. time (h)
1000	15 000	5	48	0.6	0.04
2000	15 000	5	48	1.0	0.06
5000	15 000	5	48	1.7	0.13
10 000	15 000	5	48	3.2	0.23
20 000	15 000	5	48	5.2	0.52
50 000	15 000	5	48	9.1	1.38
100 000	15 000	5	48	19.1	2.26 (1 time)
200 000	15 000	5	48	35.2	3.81 (1 time)
500 000	15 000	10	48	82.3	11.48 (1 time)
1 000 000	15 000	45	48	169.4	25.25 (1 time)