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. 2023 May 25;24(4):bbad186. doi: 10.1093/bib/bbad186

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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(A) Schematic representation of the RNA aptamer development process and (B) the significance of RNA structure in each RNA therapeutic approach. (A) The basic and exploratory research comprises multiple stages, encompassing HT-SELEX, candidate identification from the HT-SELEX output, assessment of the selected candidates’ activity and sequence truncation/optimization. (B) The importance of RNA structure (right) in three RNA-based therapeutics (left) that have been highlighted in this review.