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. 2023 Jul 4;12:e86454. doi: 10.7554/eLife.86454

Figure 6. B cell transfer from dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS)-like mice into recipient muMt- B cell-deficient mice.

Figure 6.

(a) Estrous cycles in 13-week-old muMt- mice receiving control B cells. (b) Estrous cycles in 13-week-old muMt- mice receiving DHT exposed B cells. (c) Normalized anogenital distance in 13-week-old muMt- recipient mice. (d) Weekly body weight (BW) in 13-week-old muMt- recipient mice. (e) EchoMRI record of fat and lean body composition in 13-week-old muMt- recipient mice. (f) Fasting glucose levels. (g) Oral glucose tolerance test (OgTT) in 13-week-old muMt- recipient mice. (a–g) 13-week-old muMt- mice receiving control B cells (n = 8), 13-week-old muMt- mice receiving DHT-exposed B cells (n = 9). All bars indicate means, circles represent individual mice. In the case of missing values due to lack of measurement, mice were excluded from the analysis report for that variable. Unpaired Student’s t-test for analysis of anogenital distance difference between groups, as well as EchoMRI results and fasting glucose; two-way ANOVA with Sidak’s post hoc test for analysis of weekly BW recordings and blood glucose throughout the study; *p<0.05, **p<0.01, ***p<0.001.