Table 3.
Diagnostic performance of HGF in PF in differentiating between patients with TPE and those with non-TPE according to age or/and gender.
| Variable | Cut-off value (pg/mL) | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|
| HGF, all ages | >9314.84 | 0.835 | 85.567 | 71.552 | 3.008 | 0.202 | 71.552 | 85.567 |
| (76.971–91.879) | (62.429–79.541) | (2.228–4.060) | (0.123–0.332) | (65.076–77.247) | (78.276–90.702) | |||
| M | >10695.41 | 0.847 | 77.586 | 82.192 | 4.357 | 0.273 | 77.586 | 82.192 |
| (64.728–87.491) | (71.475–90.163) | (2.611–7.269) | (0.167–0.445) | (67.477–85.240) | (73.862–88.288) | |||
| F | >7023.44 | 0.811 | 97.436 | 67.442 | 2.993 | 0.038 | 73.077 | 96.667 |
| (86.524–99.935) | (51.456–80.924) | (1.941–4.615) | (0.005–0.266) | (63.769–80.717) | (80.557–99.510) | |||
| HGF, age ≤ 65 y | >8224.00 | 0.967 | 91.860 | 91.781 | 11.176 | 0.089 | 92.941 | 90.541 |
| (83.946–96.665) | (82.964–96.924) | (5.179–24.118) | (0.043–0.181) | (85.918–96.600) | (82.426–95.130) | |||
| M | >9223.83 | 0.950 | 86.275 | 90.698 | 9.275 | 0.151 | 91.667 | 84.783 |
| (73.745–94.299) | (77.865–97.407) | (3.624–23.736) | (0.076–0.303) | (81.126–96.570) | (73.554–91.777) | |||
| F | >7023.44 | 0.988 | 97.143 | 93.333 | 14.571 | 0.031 | 94.444 | 96.552 |
| (85.083–99.928) | (77.926–99.182) | (3.815–55.657) | (0.004–0.212) | (81.654–98.483) | (80.187–99.486) |
AUC, area under the curve; PLR, positive likelihood ratio; NLR, negative likelihood ratio; PPV, positive predictive value; NPV, negative predictive value. TPE, tuberculous pleural effusion; non-TPE, non-tuberculous pleural effusion. HGF, hepatocyte growth factor; ADA, adenosine deaminase; IFN-γ, interferon gamma. M, male; F, female.