Table 4.
Diagnostic performance of ADA in PF in differentiating between patients with TPE and those with non-TPE according to age or/and gender.
| Variable | Cut-off value (U/L) | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|
| ADA, all ages | >17.80 | 0.932 | 93.814 | 84.483 | 6.046 | 0.073 | 83.486 | 94.231 |
| (87.022–97.696) | (76.589–90.536) | (3.942–9.273) | (0.034–0.160) | (76.724–88.576) | (88.229–97.267) | |||
| M | >20.60 | 0.922 | 89.655 | 86.301 | 6.545 | 0.120 | 83.871 | 91.304 |
| (78.831–96.108) | (76.247–93.231) | (3.656–11.717) | (0.056–0.257) | (74.389–90.300) | (83.037–95.749) | |||
| F | >17.80 | 0.951 | 94.872 | 88.372 | 8.159 | 0.058 | 88.095 | 95.000 |
| (82.676–99.373) | (74.917–96.115) | (3.568–18.659) | (0.015–0.225) | (76.391–94.421) | (83.064–98.660) | |||
| ADA, age ≤ 65 y | >23.00 | 0.938 | 93.023 | 86.301 | 6.791 | 0.081 | 88.889 | 91.304 |
| (85.431–97.397) | (76.247–93.231) | (3.807–12.113) | (0.037–0.176) | (81.769–93.451) | (82.839–95.805) | |||
| M | >23.10 | 0.927 | 94.118 | 86.047 | 6.745 | 0.068 | 88.889 | 92.500 |
| (83.758–98.770) | (72.068–94.702) | (3.201–14.214) | (0.023–0.206) | (79.151–94.400) | (80.344–97.383) | |||
| F | >17.80 | 0.964 | 97.143 | 90.000 | 9.714 | 0.032 | 91.892 | 96.429 |
| (85.083–99.928) | (73.471–97.888) | (3.315–28.464) | (0.005–0.220) | (79.457–97.077) | (79.582–99.468) |
AUC, area under the curve; PLR, positive likelihood ratio; NLR, negative likelihood ratio; PPV, positive predictive value; NPV, negative predictive value. TPE, tuberculous pleural effusion; non-TPE, non-tuberculous pleural effusion. HGF, hepatocyte growth factor; ADA, adenosine deaminase; IFN-γ, interferon gamma. M, male; F, female.