TABLE VIII.A.1.b.

Evidence for APAP for OSA

Study	Year	LOE	Study design	Study groups	Clinical endpoints	Conclusion
Wimms et al.1038	2019	1b	RCT	301 patients with mild OSA randomized to 1. APAP + standard care, 2. standard care	QOL from SF-36	APAP usage improved QOL in patients with mild obstructive sleep apnea.
Patil et al.39	2019	1a	SR	26 RCTs comparing APAP to CPAP	OSA severity, adherence, sleepiness, QOL, neurocognitive function	No difference between APAP and CPAP.
Lebret et al.1037	2019	1b	RCT	276 patients with OSA randomized to 1. CPAP, 2. APAP	Mask leak	PAP modality did not affect level of mask leak.
Bloch et al.1036	2018	1b	RCT	208 patients randomized to 1. CPAP, 2. APAP(5–15 cmH2O)	Subjective and objective sleepiness	APAP is effective in treating EDS.
Pepin et al.1039	2016	1b	RCT	322 patients with OSA randomized to 1. CPAP, 2. APAP	Difference in office based systolic blood pressure after 4 months of therapy	APAP can lower office based systolic blood pressure.
Ip et al.1035	2012	1a	SR	24 RCTs comparing CPAP to APAP	Adherence	Eleven-minute increase in PAP adherence with APAP.

Abbreviations: APAP, auto-titrating CPAP; BPAP, bilevel PAP; CPAP, continuous PAP; OSA, obstructive sleep apnea; PAP, positive airway pressure; QOL, quality of life; RCT, randomized control trial.