TABLE VIII.A.5.h.
Evidence for treatment of TECSA
| Study | Year | LOE | Study design | Study group | Clinical end-point | Conclusion |
|---|---|---|---|---|---|---|
| Morgenthaler et al.1052 | 2014 | 1b | RCT | 1) ASV; 2) CPAP | Primary endpoint: AHI < 10 at 90 days; Secondary endpoints: compliance, ESS, and SAQLI |
1) ASV reduces AHI more than CPAP. |
| Dellweg et al.1049 | 2013 | 1c | RCT | 1) ASV; 2) NPPV (bilevel PAP with backup rate) | Primary endpoint: AHI after 6 weeks. Secondary endpoint: AHI on ASV titration |
1) ASV showing sustained significant improvement at 6 weeks; 2) ASV and NPPV similarly treated TECSA on the titration. |
| Javaheri et al.1183 | 2011 | 1c | RCT | 1) ASV (BiPAP autoSV Advanced); 2) ASV (BiPAP autoSV) | Primary endpoint: AHI on ASV titration | 1) BiPAP autoSV Advanced lowered AHI more than BiPAP autoSV. |
| Pépin et al.1053 | 2018 | 3b | Case–control | 1) CPAP switched to ASV; 2) ASV; 3) CPAP | Primary endpoint: Adherence data; Secondary endpoint: Average AHI |
1) Increased adherence in patients switching from CPAP to ASV. 2) Lower AHI in patients switching from CPAP to ASV. |
| Heider et al.1184 | 2018 | 3b | Case–control | 1) HFpEF with TECSA; 2) HFpEF with CSA | Primary endpoint: Sleep fragmentation and quality at ASV titration and after 27 months of ASV use | 1) AHI and arousal index improve with ASV. 2) Increased sleep efficiency only in TESCA group with ASV. 3) ESS improves with ASV. |
| Neu et al.1186 | 2017 | 3b | Case–control | 1) AutoCPAP with TECSA; 2) AutoCPAP without TECSA | Primary endpoint: AHI; Secondary endpoints: Quality of life, sleep fragmentation |
1) Auto-titrating CPAP has relative treatment failure for TECSA compared to those without TECSA. |
| Kuzniar et al.1046 | 2011 | 3b | Retrospective cohort | 1) ASV (VPAP AdaptSV); 2) ASV (BiPAP autoSV) | Primary endpoint: AHI; Secondary endpoints: adherence data, sleepiness using ESS |
1) Both ASV devices were comparable. 2) Baseline populations were significantly different. |
| Allam et al.1047 | 2007 | 3bCase–control |
1) ASV; 2) CPAP; 3) BPAP-S; 4) BPAP-ST; CPAP + O2 | Primary endpoint: AHI on titration | 1) ASV reduced AHI more than other modalities. | |
| Javaheri et al.1185 | 2015 | 4 | Case series | 1) ASV using default settings | Primary endpoint: AHI; Secondary endpoints: subjective sleep quality using Likert scale and adherence and therapy data at 90 days | 1) Default ASV settings improve AHI. 2) Adherence, sleep disordered breathing, ESS, and subjective sleep quality are improved at 90 days. |
| Brown et al.1048 | 2011 | 4 | Case series | 1) ASV | Primary endpoint: AHI on titration | ASV can be effective in reducing AHI. |