. Author manuscript; available in PMC: 2024 Jan 1.

Published in final edited form as: Int Forum Allergy Rhinol. 2023 Mar 30;13(7):1061–1482. doi: 10.1002/alr.23079

TABLE VIII.A.6.i.

PAP and improvement in insomnia

Study	Year	LOE	Study design	Study groups	Clinical endpoint	Conclusion
Glidewell et al.¹³²³	2014	4	Retrospective cohort study	Archival data from 68 PAP-treated sleep apnea patients	Insomnia Severity Index (ISI), PSG	For the 53 patients with pretreatment insomnia symptoms, ISI scores improved in 45.3% and persisted in 54.7% following PAP treatment.
Bjornsdottir et al.⁹⁴³	2013	3b	Prospective longitudinal cohort study	705 adults with OSA	Basic Nordic Sleep Questionnaire, HSAT	Symptoms of sleep maintenance insomnia improved significantly among patients using PAP (from 59.4% to 30.7%, p < 0.001). Symptoms of initial insomnia tended to persist regardless of PAP treatment, and symptoms of late insomnia were more likely to improve among patients not using PAP.
Sweetman et al.¹¹⁹⁰	2019	2	Prospective trial	73 adults treated with CPAP. Those who had CBTi were excluded	ISI (6-months)	CPAP therapy led to a 36% improvement in ISI.