Table 1.
Baseline clinicopathologic characteristics of mCRC patients with different metastases
| Variables | Total (n = 7995) | No. of patients (%) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver metastases | Lung metastases | Bone metastases | Brain metastases | ||||||||||
| Yes (n = 6031) | No (n = 1964) | P value | Yes (n = 1614) | No (n = 6381) | P value | Yes (n = 280) | No (n = 7715) | P value | Yes (n = 70) | No (n = 7925) | P value | ||
| Age | 0.047* | 0.019* | 0.437 | 0.559 | |||||||||
| ≤ 60 | 4502 (56.3) | 3434 (56.9) | 1068 (54.4) | 867 (53.7) | 3635 (57.0) | 164 (58.6) | 4338 (56.2) | 37 (52.9) | 4465 (56.3) | ||||
| > 60 | 3493 (43.7) | 2597 (43.1) | 896 (45.6) | 747 (46.3) | 2746 (43.0) | 116 (41.4) | 3377 (43.8) | 33 (47.1) | 3460 (43.7) | ||||
| Sex | 0.008* | 0.003* | 0.446 | 0.335 | |||||||||
| Female | 3317 (41.5) | 2452 (40.7) | 865 (44.0) | 722 (44.7) | 2595 (40.7) | 110 (39.3) | 3207 (41.6) | 33 (47.1) | 3284 (41.4) | ||||
| Male | 4678 (58.5) | 3579 (59.3) | 1099 (56.0) | 892 (55.3) | 3786 (59.3) | 170 (60.7) | 4508 (58.4) | 37 (52.9) | 4641 (58.6) | ||||
| Race | 0.133 | 0.034* | 0.938 | 0.360 | |||||||||
| White | 5982 (74.8) | 4542 (75.3) | 1440 (73.3) | 1172 (72.6) | 4810 (75.4) | 212 (75.7) | 5770 (74.8) | 56 (80.0) | 5926 (74.8) | ||||
| Black | 1137 (14.2) | 848 (14.1) | 286 (14.6) | 238 (14.7) | 896 (14.0) | 38 (13.6) | 1096 (14.2) | 10 (14.3) | 1124 (14.2) | ||||
| Other | 879 (11.0) | 641 (10.6) | 238 (12.1) | 204 (12.7) | 675 (10.6) | 30 (10.7) | 849 (11.0) | 4 (5.7) | 875 (11.0) | ||||
| Primary site | < 0.001* | < 0.001* | 0.002* | 0.007* | |||||||||
| Right colon | 1417 (17.7) | 1105 (18.3) | 312 (15.9) | 242 (15.0) | 1175 (18.4) | 48 (17.2) | 1369 (17.7) | 22 (31.4) | 1395 (17.6) | ||||
| Transverse colon | 590 (7.4) | 458 (7.6) | 132 (6.7) | 109 (6.8) | 481 (7.5) | 21 (7.5) | 569 (7.4) | 2 (2.9) | 588 (7.4) | ||||
| Left colon | 3132 (39.2) | 2474 (41.0) | 658 (33.5) | 556 (34.4) | 2576 (40.4) | 83 (29.6) | 3049 (39.5) | 19 (27.1) | 3113 (39.3) | ||||
| Rectum | 2856 (35.7) | 1994 (33.1) | 862 (43.9) | 707 (43.8) | 2149 (33.7) | 128 (45.7) | 2728 (35.4) | 27 (38.6) | 2829 (35.7) | ||||
| Tumor size (cm) | 5.60 | 5.55 | 5.76 | 0.004* | 5.76 | 5.56 | 0.038* | 5.75 | 5.59 | 0.128 | 5.87 | 5.60 | 0.171 |
| Grade | 0.308 | 0.222 | < 0.001* | 0.161 | |||||||||
| I | 361 (4.5) | 263 (4.3) | 98 (5.0) | 85 (5.3) | 276 (4.3) | 9 (3.2) | 352 (4.6) | 4 (5.7) | 357 (4.5) | ||||
| II | 5801 (72.6) | 4400 (73.0) | 1401 (71.3) | 1180 (73.1) | 4621 (72.4) | 174 (62.1) | 5627 (72.9) | 47 (67.1) | 5754 (72.6) | ||||
| III | 1553 (19.4) | 1152 (19.1) | 401 (20.4) | 299 (18.5) | 1254 (19.7) | 83 (29.7) | 1470 (19.1) | 19 (27.2) | 1534 (19.4) | ||||
| IV | 280 (3.5) | 216 (3.6) | 64 (3.3) | 50 (3.1) | 230 (3.6) | 14 (5.0) | 266 (3.4) | 0 (0.0) | 280 (3.5) | ||||
| Histology | 0.741 | 0.941 | 0.278 | 0.351 | |||||||||
| Mucinous adenocarcinoma | 428 (5.4) | 320 (5.3) | 108 (5.5) | 87 (5.4) | 341 (5.3) | 19 (6.8) | 409 (5.3) | 2 (2.9) | 426 (5.4) | ||||
| Adenocarcinoma | 7567 (94.6) | 5711 (94.7) | 1856 (94.5) | 1527 (94.6) | 6040 (94.7) | 261 (93.2) | 7306 (94.7) | 68 (97.1) | 7499 (94.6) | ||||
| AJCC T stage | < 0.001* | < 0.001* | < 0.001* | 0.562 | |||||||||
| T1 | 682 (8.6) | 465 (7.7) | 217 (11.0) | 171 (10.6) | 511 (8.0) | 37 (13.2) | 645 (8.3) | 9 (12.9) | 673 (8.5) | ||||
| T2 | 273 (3.4) | 205 (3.4) | 68 (3.5) | 55 (3.4) | 218 (3.4) | 10 (3.6) | 263 (3.4) | 3 (4.2) | 270 (3.4) | ||||
| T3 | 4449 (55.6) | 3456 (57.3) | 993 (50.5) | 831 (51.5) | 3618 (56.7) | 124 (44.3) | 4325 (56.1) | 38 (57.3) | 4411 (55.7) | ||||
| T4 | 2591 (32.4) | 1905 (31.6) | 686 (35.0) | 557 (34.5) | 2034 (31.9) | 109 (38.9) | 2482 (32.2) | 20 (28.6) | 2571 (32.4) | ||||
| AJCC N stage | 0.234 | 0.044* | 0.767 | 0.021* | |||||||||
| NO | 1856 (23.2) | 1378 (22.8) | 478 (24.3) | 401 (24.8) | 1455 (22.8) | 60 (21.4) | 1796 (23.3) | 17 (24.3) | 1839 (23.2) | ||||
| N1 | 3370 (42.2) | 2537 (42.1) | 833 (42.4) | 694 (43.0) | 2676 (41.9) | 120 (42.9) | 3250 (42.1) | 19 (27.1) | 3351 (42.3) | ||||
| N2 | 2769 (34.6) | 2116 (35.1) | 653 (33.3) | 519 (32.2) | 2250 (35.3) | 100 (35.7) | 2669 (34.6) | 34 (48.6) | 2735 (34.5) | ||||
| Radiation | < 0.001* | < 0.001* | < 0.001* | <0.001* | |||||||||
| No/unknown | 6674 (83.5) | 5199 (86.2) | 1475 (75.1) | 1278 (79.2) | 5396 (84.6) | 172 (61.4) | 6502 (84.3) | 25 (35.7) | 6649 (83.9) | ||||
| Yes | 1321 (16.5) | 832 (13.8) | 489 (24.9) | 336 (20.8) | 985 (15.4) | 108 (38.6) | 1213 (15.7) | 45 (64.3) | 1276 (16.1) | ||||
| Chemotherapy | 0.008* | 0.075 | 0.749 | < 0.001* | |||||||||
| No/unknown | 1343 (16.8) | 975 (16.2) | 368 (18.7) | 295 (18.3) | 1048 (16.4) | 49 (17.5) | 1294 (16.8) | 24 (34.3) | 1319 (16.6) | ||||
| Yes | 6652 (83.2) | 5056 (83.8) | 1596 (81.3) | 1319 (81.7) | 5333 (83.6) | 231 (82.5) | 6421 (83.2) | 46 (65.7) | 6606 (83.4) | ||||
| CEA level | 0.687 | 0.291 | 0.729 | < 0.001* | |||||||||
| Negative | 1404 (17.6) | 1065 (17.7) | 339 (17.3) | 269 (16.7) | 1135 (17.8) | 47 (16.8) | 1357 (17.6) | 23 (32.9) | 1381 (17.4) | ||||
| Positive | 6591 (82.4) | 4966 (82.3) | 1625 (82.7) | 1345 (83.3) | 5246 (82.2) | 233 (83.2) | 6358 (82.4) | 47 (67.1) | 6544 (82.6) | ||||