Table 1.
Mendelian randomization results of the top 5 correlations of the BIDPs to BMD among each part (FDR P < 0.01)
| No. | UKBID | IDP.short.name | Category name | Outcome | Method | SNP | OR | p | FDR |
|---|---|---|---|---|---|---|---|---|---|
| 187 | 26536 |
aseg_global_volume- ratio_BrainSegVol-to-eTIV |
aseg:global | FN BMD | IVW | 15 | 1.50 | 7.35E-08 | 1.69E-06 |
| 172 | 26521 |
aseg_global_volume_ EstimatedTotalIntraCranial |
aseg:global | FN BMD | IVW | 7 | 1.42 | 1.92E-04 | 2.20E-03 |
| 36 | 25792 |
IDP_T1_FAST_ROIs_ L_inf_front_gyrus_parsop |
IDP T1 | FN BMD | WR | 1 | 1.96 | 2.33E-05 | 3.05E-03 |
| 9 | 25009 |
IDP_T1_SIENAX_ brain-normalized_volume |
IDP T1:global | FN BMD | IVW | 9 | 1.29 | 5.85E-04 | 7.73E-03 |
| 187 | 26536 |
aseg_global_volume- ratio_BrainSegVol-to-eTIV |
aseg:global | Forearm BMD | IVW | 15 | 0.51 | 1.11E-08 | 2.55E-07 |
| 661 | 26734 |
aparc-Desikan_ lh_area_medialorbitofrontal |
Desikan Atlas | Heel BMD | WR | 1 | 0.61 | 1.45E-34 | 2.73E-32 |
| 36 | 25792 |
IDP_T1_FAST_ROIs_ L_inf_front_gyrus_parsop |
IDP T1 | Heel BMD | WR | 1 | 1.55 | 1.00E-28 | 1.31E-26 |
| 356 | 26801 |
aparc-Desikan_lh_ volume_medialorbitofrontal |
Desikan Atlas | Heel BMD | WR | 1 | 1.59 | 3.00E-28 | 3.51E-26 |
| 1 033 | 26768 |
aparc-Desikan_lh_ thickness_medialorbitofrontal |
Desikan Atlas | Heel BMD | WR | 1 | 0.66 | 9.89E-26 | 3.12E-24 |
| 1 038 | 26773 |
aparc-Desikan_lh_ thickness_parsorbitalis |
Desikan Atlas | Heel BMD | WR | 1 | 0.64 | 7.20E-26 | 3.12E-24 |
| 187 | 26536 |
aseg_global_v olume-ratio_BrainSegVol-to-eTIV |
aseg:global | LS BMD | IVW | 15 | 0.59 | 4.52E-09 | 1.04E-07 |
| 1 028 | 26763 |
aparc-Desikan_lh_t hickness_inferiortemporal |
Desikan Atlas | LS BMD | IVW | 4 | 0.64 | 1.61E-06 | 1.01E-04 |
| 1 214 | 27439 |
aparc-a2009s_lh_ thickness_G-temporal-inf |
Destrieux Atlas | LS BMD | IVW | 5 | 0.66 | 6.02E-05 | 7.34E-03 |
| 93 | 25849 |
IDP_T1_FAST_ROIs_R_ parahipp_gyrus_ant |
IDP T1 | LS BMD | IVW | 2 | 1.81 | 6.24E-05 | 8.17E-03 |
| 1 237 | 27462 |
aparc-a2009s_lh_ thickness_S-oc-temp-lat |
Destrieux Atlas | LS BMD | WR | 1 | 0.54 | 1.74E-04 | 8.51E-03 |
| 187 | 26536 | aseg_global_volume-ratio_BrainSegVol-to-eTIV | aseg:global | TB BMD | IVW | 17 | 0.44 | 4.00E-28 | 9.20E-27 |
| 661 | 26734 |
aparc-Desikan_lh_ area_medialorbitofrontal |
Desikan Atlas | TB BMD | WR | 1 | 0.38 | 6.38E-14 | 1.20E-11 |
| 810 | 27143 |
aparc-DKTatlas_lh_ area_caudalanteriorcingulate |
Desikan Atlas | TB BMD | WR | 1 | 1.53 | 1.30E-05 | 1.22E-03 |
| 506 | 27483 |
aparc-a2009s_lh_ volume_G + S-cingul-Mid-Ant |
Destrieux Atlas | TB BMD | WR | 1 | 1.66 | 1.30E-05 | 1.61E-03 |
| 505 | 27482 |
aparc-a2009s_lh_ volume_G + S-cingul-Ant |
Destrieux Atlas | TB BMD | WR | 1 | 1.73 | 5.25E-05 | 3.26E-03 |
IVW inverse-variance weighted, WR Wald ratio, FN BMD femoral neck BMD, LS BMD lumbar spine BMD, TB BMD total body BMD