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. 2023 Jul 20;14:4369. doi: 10.1038/s41467-023-39982-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Beginning with isolating 252 A. fumigatus strains from hospitals and soil, we generated a comprehensive pan-GEM for deriving 252 strain-specific GEMs. By including lung microbiome analysis and simulating fungal-lung microbiome interactions, we predicted and experimentally tested nutritional environments for supporting lung bacteria that impact A. fumigatus growth. Both lung bacterial communities and metabolites have the potential to affect A. fumigatus growth and thus the effectiveness of drugs to treat infections by this opportunistic fungal pathogen.