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. 2023 Jul 20;13:11737. doi: 10.1038/s41598-023-38127-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of proteins differentially expressed in wAu, wAlbA and wt midguts of Aedes aegypti. Pooled midguts were analysed by mass spectrometry to determine proteins that show significant alterations in expression between midguts containing wAu, wAlbA and wt (uninfected) N = 5. (a) Principal component analysis of all quantified proteins, each dot represents a single replicate. (b) Clustered heatmap of significantly dysregulated proteins when wAu or wAlbA are present compared to wt. (c) mass spectrometry quantitation of 3379 proteins identified from midguts of Ae. aegypti. Proteins present at significantly different levels are highlighted in red (up regulated) or blue (down regulated), dashed line denotes p-value threshold for a false discovery rate of 5%. Top 20 differentially regulated Aedes proteins are labelled, with most enriched Wolbachia proteins in grey.