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. 2023 Jul 20;14(7):452. doi: 10.1038/s41419-023-05976-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Increased expression of cancer stem cell markers (NANOG, OCT4, SOX2, and CD44) in MGC803-circSLC4A7 cells and SGC7901-circSLC4A7 cells was reversed after transfection with siHSP90. B The increase in the number of tumor spheres comprising after MGC803-circSLC4A7 cells and SGC7901-circSLC4A7 cells per well was reduced after the cells were transfected siHSP90. C The increased proportions of CD44+/CD54+ cells were reduced after cell transfection with siHSP90. The data represent at least three independent experiments. D The upregulated expression of NANOG after circSLC4A7 overexpression in MGC803 and SGC7901 cells was suppressed after cell transfection with siHSP90. (scale bar, 20 μm) **P < 0.01 based on the one-way ANOVA. All results are from three independent experiments. Data are represented as mean ± SD. At least one representative image was captured.