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. 2023 Jul 20;14(7):452. doi: 10.1038/s41419-023-05976-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Detection of genes involved in signaling pathways regulating stemness, as measured by qRT-PCR. B HSP90 interference reversed the increase of mRNAs levels of NOTCH1 and downstream molecules caused by circSLC4A7 overexpression by qRT-PCR, and HSP90 overexpression reversed the suppression of mRNAs levels of NOTCH1 and downstream molecules caused by circSLC4A7 interference by qRT-PCR. C siHSP90 reversed the upregulation of NOTCH1 and downstream molecules caused by the ectopic overexpression of circSLC4A7, overexpression of HSP90 reversed the suppression of NOTCH1 and downstream molecules caused by circSLC4A7 interference. **P < 0.01 based on the one-way ANOVA. All results are from three independent experiments. Data are represented as mean ± SD. At least one representative image was captured.