Table 2.
Effect of carob methanol extract (CME) and vitamin C on kidney functions parameters in the serum of rats with doxorubicin-induced nephrotoxicity (mean ± SE, n = 6)
| Groups | Creatinine (mg/dl) |
Urea (mg/dl) |
Sodium (mEq/l) |
Potassium (mEq/l) |
Chloride (mEq/l) |
Calcium (mg/dl) |
|---|---|---|---|---|---|---|
| Control | 0.27 ± 0.02c | 38.69 ± 6.4c | 134.06 ± 3.4c | 4.38 ± 0.47b | 100.66 ± 3.3 | 10.89 ± 0.2a |
| Doxorubicin | 0.68 ± 0.13a | 55.56 ± 7.0a | 143.13 ± 2.8a | 5.45 ± 0.78a | 97.76 ± 3.8 | 9.87 ± 0.2c |
| Vitamin C (250 mg/kg b.wt.) | 0.45 ± 0.06b | 46.46 ± 7.2b | 135.75 ± 3.1bc | 4.54 ± 0.34b | 98.10 ± 2.2 | 10.37 ± 0.1b |
| CME500 mg/kg b.wt. | 0.52 ± 0.07b | 46.69 ± 4.3b | 136.54 ± 1.7bc | 4.62 ± 0.25b | 98.40 ± 1.3 | 10.42 ± 0.2b |
| CME1000 mg/kg b.wt. | 0.53 ± 0.05b | 47.10 ± 4.7b | 138.89 ± 2.2b | 4.92 ± 0.21ab | 99.74 ± 1.8 | 10.57 ± 0.3b |
| P-value | P = 0.001 | P = 0.002 | P = 0.001 | P = 0.004 | P = 0.07 | P = 0.01 |
Means with different superscripts in the same column are significantly different at P < 0.05