Table 3.
Effect of carob methanol extract (CME) and vitamin C on oxidative stress markers in the kidney tissue homogenate of rats treated with doxorubicin-induced nephrotoxicity (mean ± SE, n = 6)
| Groups | GSH (nMol/100 mg protein) |
GST (nMol/min/mg protein) |
Catalase (pg/ml) |
SOD (U/ml tissue) |
MDA (mMol/g tissue) |
|---|---|---|---|---|---|
| Control | 3.00 ± 0.80c | 0.32 ± 0.02a | 83.33 ± 9.44b | 73.80 ± 2.71b | 8.48 ± 0.36b |
| Doxorubicin | 0.70 ± 0.10d | 0.26 ± 0.01b | 45.00 ± 2.98d | 66.60 ± 6.56c | 10.18 ± 1.54a |
| Vitamin C (250 mg/kg b.wt.) | 9.20 ± 1.10a | 0.27 ± 0.042b | 62.50 ± 1.77c | 83.80 ± 1.60b | 7.72 ± 0.33b |
| CME500 mg/kg b.wt. | 7.80 ± 0.70b | 0.32 ± 0.05a | 91.50 ± 8.60a | 79.20 ± 9.52b | 7.87 ± 0.05b |
| CME1000 mg/kg b.wt. | 8.90 ± 1.40a | 0.25 ± 0.01b | 60.00 ± 7.07c | 90.80 ± 3.87a | 6.55 ± 0.43c |
| P-value | P = 0.001 | P = 0.001 | P = 0.001 | P = 0.001 | P = 0.001 |
Means with different superscripts in the same column are significantly different at P < 0.05
GSH reduced glutathione, GST glutathione-s-transferase, SOD superoxide dismutase, MDA malondialdehyde