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. 2023 Jul 20;14:4400. doi: 10.1038/s41467-023-39985-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A UMAP of cisplatin treated PDX (patient derived xenograft) cells annotated by time point (left) and treatment status (right). B Metagenes plotted with respect to regression coefficients (β_treated and β_untreated) over four timepoints in either treated or untreated cells with Bonferroni adjusted p-values = 0.001. C Hallmark combined enrichment scores for candidate chemo resistant metagenes. D Gene expression profiles for each timepoint for the five metagenes associated with increase in treatment. Metagene 24 is associated with TGF-beta signaling includes EPCAM, FOXP1, and ID family genes with known cisplatin resistance function. E Most similar genes for treated and untreated cells computed from cosine similarity to global vectors. Source data provided as a Source Data file.