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. 2023 Mar 31;94(8):589–596. doi: 10.1136/jnnp-2022-330848

Figure 1.

Figure 1

Predicted trajectories of EDSS, MSIS-PHYS and SMDT scores over a 15-year period post diagnosis, by smoking status at diagnosis. Based on data in online supplemental table 5. The lines represent β coefficients from the linear mixed effects model adjusted for sex, duration between onset-diagnosis, disease-modifying treatment, age at diagnosis, disease phenotype and baseline EDSS. Models considered a non-linear trajectory with quadratic time (with corresponding random effects). EDSS, Expanded Disability Status Scale; MSIS-PHYS, Multiple Sclerosis Impact Scale physical score; SMDT, Symbol Digit Modalities Test.