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. 2023 Mar 23;72(8):1472–1485. doi: 10.1136/gutjnl-2022-328048

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Potential determinants of faecal metabolite levels. (A) Bar plot showing the number of significant associations between phenotypes and metabolites in each of the cohorts and in the meta-analysis (online supplemental table 11). Only phenotypes with more than three associations are shown. Red labels indicate phenotypes exclusively available for cases and blue labels for controls. (B). Correlation plot showing the relation between AAMU (expressed as clr-transformed AUC values) and coffee consumption (x-axis) per cohort. Coffee consumption is represented as the estimated consumption per day (grams/day) adjusted by overall individual calorie intake (see online supplemental methods). (C). Boxplots showing the levels of 1-palmitoylglycerol (16:0). Boxplot shows the median and IQR (25th and 75th). Whiskers show the 1.5*IQR range. Data distribution is represented by background violin-plot. Lines in the correlation plot show linear regression and shadows indicate the 95% CI. AAMU, 5-acetylamino-6-amino-3-methyluracil; AUC, area under the curve.