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. 2023 Mar 23;72(8):1472–1485. doi: 10.1136/gutjnl-2022-328048

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Metabolic signature of patients with intestinal dysbiosis. (A) Principal coordinate analysis on microbiome composition per sample (dots). Colours indicate disease phenotypes: CD (purple), UC (green), IBD-undetermined (pink), non-IBD (black). (B) Red dots depict samples considered to be dysbiotic based on the median distance to non-IBD samples. (C) Volcano plot showing the p value (y-axis) and regression coefficients (x-axis, positive values indicate enrichment in dysbiosis) of the association analyses between dysbiotic and non-dysbiotic IBD samples (online supplemental table 5). Dot colour indicates pathway annotations provided by Metabolon (online supplemental table 2). CD, Crohn’s disease; IBD, inflammatory bowel disease; UC, ulcerative colitis.