Table 2.
Network league table.
| GLP-1RA | ||||||||||||||||||
| 1.63 (0.54,4.87) | Met | STEP1 | ||||||||||||||||
| 7.54 (3.39,16.78) | 4.64 (1.20,17.99) | Insulin | ||||||||||||||||
| 1.16 (0.11,11.72) | 0.71 (0.06,9.21) | 0.15 (0.01,1.78) | SU | |||||||||||||||
| 11.78 (2.90,47.90) | 7.25 (1.22,43.02) | 1.56 (0.31,7.85) | 10.19 (0.68,152.60) | SGLT2 | ||||||||||||||
| 4.20 (1.76,10.05) | 2.58 (0.64,10.40) | 0.56 (0.17,1.82) | 3.63 (0.33,39.61) | 0.36 (0.07,1.86) | DPP4 | |||||||||||||
| 6.89 (1.19,39.80) | 4.24 (0.56,32.28) | 0.91 (0.13,6.22) | 5.96 (0.33,106.95) | 0.59 (0.06,5.52) | 1.64 (0.25,10.58) | TZD | ||||||||||||
| 4.84 (3.45,6.79) | 2.98 (0.94,9.45) | 0.64 (0.27,1.54) | 4.19 (0.40,43.42) | 0.41 (0.10,1.74) | 1.15 (0.46,2.91) | 0.70 (0.12,4.18) | Placebo | |||||||||||
| 4.41 (1.34,14.58) | 2.72 (0.53,13.79) | 0.59 (0.14,2.47) | 3.82 (0.28,51.64) | 0.37 (0.06,2.36) | 1.05 (0.24,4.60) | 0.64 (0.08,5.34) | 0.91 (0.26,3.14) | Blank | ||||||||||
| Exenatide | ||||||||||||||||||
| 0.50 (0.29,0.86) | Liraglutide | STEP2 | ||||||||||||||||
| 1.67 (0.67,4.13) | 3.36 (1.31,8.57) | Dulaglutide | ||||||||||||||||
| 0.52 (0.28,1.00) | 1.06 (0.50,2.24) | 0.31 (0.12,0.86) | Semaglutide | |||||||||||||||
| 0.62 (0.07,5.31) | 1.24 (0.14,10.98) | 0.37 (0.04,3.66) | 1.18 (0.13,10.34) | Tirzepatide | ||||||||||||||
| 0.53 (0.26,1.07) | 1.07 (0.44,2.62) | 0.32 (0.10,1.00) | 1.01 (0.39,2.63) | 0.86 (0.09,8.31) | Taspoglutide | |||||||||||||
| 1.83 (0.58,5.74) | 3.68 (1.12,12.12) | 1.10 (0.34,3.56) | 3.49 (0.98,12.43) | 2.97 (0.27,33.24) | 3.45 (0.90,13.22) | Met | ||||||||||||
| 6.52 (2.83,15.03) | 13.14 (5.47,31.56) | 3.91 (1.36,11.24) | 12.45 (4.65,33.35) | 10.59 (1.08,104.03) | 12.30 (4.12,36.69) | 3.57 (0.93,13.61) | Insulin | |||||||||||
| 1.08 (0.11,10.55) | 2.17 (0.21,22.52) | 0.65 (0.06,7.42) | 2.05 (0.20,21.52) | 1.75 (0.08,40.00) | 2.03 (0.19,22.12) | 0.59 (0.05,7.49) | 0.17 (0.01,1.86) | SU | ||||||||||
| 6.18 (1.41,27.09) | 12.44 (2.70,57.43) | 3.71 (0.70,19.64) | 11.78 (3.11,44.59) | 10.03 (0.78,128.27) | 11.64 (2.26,59.91) | 3.38 (0.54,21.26) | 0.95 (0.18,4.96) | 5.73 (0.39,85.30) | SGLT2i | |||||||||
| 3.24 (1.32,7.96) | 6.53 (2.42,17.63) | 1.94 (0.61,6.24) | 6.18 (2.48,15.38) | 5.26 (0.53,52.25) | 6.11 (1.95,19.15) | 1.77 (0.44,7.15) | 0.50 (0.15,1.62) | 3.01 (0.28,31.95) | 0.52 (0.10,2.63) | DPP4i | ||||||||
| 6.53 (1.15,37.22) | 13.16 (2.15,80.71) | 3.92 (0.57,27.02) | 12.47 (2.01,77.34) | 10.60 (0.67,167.43) | 12.32 (1.88,80.52) | 3.57 (0.47,27.22) | 1.00 (0.15,6.76) | 6.07 (0.35,104.95) | 1.06 (0.11,10.13) | 2.02 (0.32,12.88) | TZD | |||||||
| 3.45 (2.27,5.24) | 6.95 (4.07,11.86) | 2.07 (0.85,5.03) | 6.58 (3.95,10.96) | 5.60 (0.68,46.35) | 6.50 (2.87,14.76) | 1.89 (0.59,6.08) | 0.53 (0.22,1.26) | 3.20 (0.32,32.25) | 0.56 (0.13,2.32) | 1.06 (0.43,2.61) | 0.53 (0.09,3.11) | Placebo | ||||||
| 4.73 (1.46,15.37) | 9.54 (2.60,35.03) | 2.84 (0.64,12.52) | 9.03 (2.38,34.27) | 7.68 (0.66,89.20) | 8.92 (2.26,35.22) | 2.59 (0.50,13.36) | 0.73 (0.17,3.07) | 4.40 (0.34,57.24) | 0.77 (0.12,5.04) | 1.46 (0.33,6.40) | 0.72 (0.09,5.92) | 1.37 (0.40,4.75) | Blank | |||||
| Taspoglutide | ||||||||||||||||||
| 1.88 (0.66,5.38) | Exenatide b.i.d | STEP3 | ||||||||||||||||
| 2.06 (0.44,9.69) | 1.10 (0.35,3.41) | Exenatide q.w | ||||||||||||||||
| 5.24 (0.15,177.48) | 2.78 (0.10,80.28) | 2.54 (0.09,74.40) | PEX168 | |||||||||||||||
| 0.38 (0.01,10.00) | 0.20 (0.01,4.46) | 0.19 (0.01,4.14) | 0.07 (0.00,5.98) | ITCA650 | ||||||||||||||
| 0.69 (0.14,3.36) | 0.37 (0.11,1.20) | 0.34 (0.11,1.07) | 0.13 (0.00,3.94) | 1.82 (0.08,41.34) | Lixisenatide | |||||||||||||
| 3.67 (0.47,28.80) | 1.95 (0.33,11.48) | 1.78 (0.37,8.45) | 0.70 (0.02,26.39) | 9.60 (0.33,282.06) | 5.28 (0.96,29.06) | Efpeglenatide q.w | ||||||||||||
| 1.09 (0.06,20.63) | 0.58 (0.04,9.03) | 0.53 (0.04,7.40) | 0.21 (0.00,13.67) | 2.84 (0.05,151.34) | 1.56 (0.10,24.33) | 0.30 (0.02,4.15) | Efpeglenatide q.m | |||||||||||
| 0.53 (0.08,3.35) | 0.28 (0.06,1.29) | 0.26 (0.06,1.09) | 0.10 (0.00,3.38) | 1.38 (0.05,35.82) | 0.76 (0.19,3.05) | 0.14 (0.02,1.04) | 0.49 (0.03,8.84) | Semaglutide q.w | ||||||||||
| 2.05 (0.37,11.46) | 1.09 (0.28,4.26) | 0.99 (0.24,4.03) | 0.39 (0.01,12.01) | 5.36 (0.23,126.26) | 2.95 (0.70,12.44) | 0.56 (0.08,3.86) | 1.89 (0.11,32.56) | 3.89 (0.70,21.47) | oral Semaglutide | |||||||||
| 4.66 (0.63,34.55) | 2.47 (0.45,13.63) | 2.26 (0.34,14.90) | 0.89 (0.02,37.03) | 12.19 (0.37,398.55) | 6.71 (0.94,48.10) | 1.27 (0.12,13.35) | 4.29 (0.18,101.36) | 8.85 (1.00,78.42) | 2.28 (0.27,18.85) | Met | ||||||||
| 7.61 (1.49,38.97) | 4.04 (1.16,14.13) | 3.69 (1.07,12.69) | 1.45 (0.04,47.84) | 19.92 (0.78,505.96) | 10.97 (2.63,45.68) | 2.08 (0.31,13.89) | 7.01 (0.41,121.34) | 14.45 (2.56,81.71) | 3.72 (0.70,19.65) | 1.63 (0.21,12.47) | Insulin | |||||||
| 1.76 (0.13,24.10) | 0.93 (0.08,10.27) | 0.85 (0.07,11.13) | 0.34 (0.01,20.08) | 4.60 (0.10,221.11) | 2.53 (0.20,32.64) | 0.48 (0.03,8.77) | 1.62 (0.04,58.95) | 3.34 (0.22,51.08) | 0.86 (0.06,12.81) | 0.38 (0.02,6.99) | 0.23 (0.02,3.29) | SU | ||||||
| 24.12 (2.39,243.26) | 12.80 (1.63,100.37) | 11.68 (1.45,93.90) | 4.60 (0.11,196.91) | 63.12 (1.88,2123.40) | 34.75 (4.22,286.29) | 6.58 (0.56,77.97) | 22.22 (0.87,566.75) | 45.80 (4.59,457.33) | 11.78 (2.52,55.03) | 5.18 (0.38,70.84) | 3.17 (0.33,30.62) | 13.71 (0.61,307.49) | SGLT2i | |||||
| 3.62 (0.72,18.24) | 1.92 (0.56,6.58) | 1.75 (0.58,5.30) | 0.69 (0.02,21.07) | 9.46 (0.40,221.42) | 5.21 (2.21,12.30) | 0.99 (0.17,5.61) | 3.33 (0.21,52.55) | 6.87 (1.98,23.75) | 1.77 (0.39,7.91) | 0.78 (0.11,5.57) | 0.47 (0.11,2.03) | 2.06 (0.16,25.93) | 0.15 (0.02,1.29) | DPP4i | ||||
| 11.10 (1.28,95.91) | 5.89 (0.89,38.77) | 5.37 (0.82,35.06) | 2.12 (0.05,90.87) | 29.04 (0.86,980.07) | 15.98 (2.22,115.06) | 3.03 (0.29,32.05) | 10.22 (0.43,244.70) | 21.07 (2.37,187.09) | 5.42 (0.62,47.29) | 2.38 (0.22,26.04) | 1.46 (0.18,11.61) | 6.31 (0.32,125.34) | 0.46 (0.03,6.57) | 3.07 (0.44,21.29) | TZD | |||
| 8.98 (2.33,34.60) | 4.76 (2.04,11.13) | 4.35 (1.76,10.77) | 1.71 (0.07,44.35) | 23.50 (1.20,459.36) | 12.93 (4.94,33.86) | 2.45 (0.49,12.25) | 8.27 (0.59,115.89) | 17.05 (4.50,64.57) | 4.39 (1.50,12.80) | 1.93 (0.31,11.93) | 1.18 (0.33,4.22) | 5.10 (0.43,60.97) | 0.37 (0.06,2.43) | 2.48 (0.87,7.09) | 0.81 (0.12,5.32) | Placebo | ||
| 3.53 (0.38,32.87) | 1.88 (0.26,13.42) | 1.71 (0.25,11.59) | 0.67 (0.02,29.33) | 9.25 (0.27,316.66) | 5.09 (0.73,35.40) | 0.96 (0.09,10.34) | 3.26 (0.13,79.02) | 6.71 (0.73,62.10) | 1.73 (0.19,15.42) | 0.76 (0.06,9.49) | 0.46 (0.05,3.95) | 2.01 (0.10,41.96) | 0.15 (0.01,2.13) | 0.98 (0.13,7.22) | 0.32 (0.02,4.10) | 0.39 (0.06,2.66) | Blank | |
| 0.85 (0.13,5.55) | 0.45 (0.10,2.13) | 0.41 (0.13,1.29) | 0.16 (0.00,5.55) | 2.24 (0.08,58.85) | 1.23 (0.27,5.65) | 0.23 (0.06,0.93) | 0.79 (0.06,10.54) | 1.62 (0.28,9.52) | 0.42 (0.07,2.36) | 0.18 (0.02,1.60) | 0.11 (0.02,0.58) | 0.49 (0.03,7.78) | 0.04 (0.00,0.36) | 0.24 (0.05,1.06) | 0.08 (0.01,0.67) | 0.10 (0.02,0.37) | 0.24 (0.03,2.16) | Liraglutide |
| Semaglutide 0.5mg q.w | ||||||||||||||||||
| 0.66 (0.47,0.91) | Semaglutide 1.0mg q.w | STEP4 | ||||||||||||||||
| 25.68 (1.55,425.32) | 39.07 (2.37,644.60) | Insulin | ||||||||||||||||
| 6.55 (3.77,11.37) | 9.96 (5.71,17.36) | 0.25 (0.01,4.41) | Placebo | |||||||||||||||
| 8.25 (2.51,27.05) | 12.55 (3.84,40.98) | 0.32 (0.02,6.69) | 1.26 (0.35,4.57) | DPP4i |
Positive results were highlighted in blue.