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. 2023 May 31;51(13):6634–6653. doi: 10.1093/nar/gkad468

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Dynamic chromatin architecture in human erythropoiesis. (A) Schematic description of ex vivo CD34 + erythroid cell differentiation and subsequent separation of HSPC, Ery-Pro, and Ery-Pre cells and illustration of the experimental strategy. (B) Micro-C contact probability as a function of distance in HSPC (blue), Ery-Pro (orange) and Ery-Pre (green) cells. (C) Changes in compartment dynamics during human erythropoiesis. (D) Heatmap showing the boundary strength of HSPC, Ery-Pro and Ery-Pre cells at ±0.5 Mb of boundary regions. (E) Micro-C Hi-C contact matrices and domain scores (top) and H3K27ac signals (middle) of HSPC, Ery-Pro and Ery-Pre stages, and RNA expression (bottom) in HSPC and Ery-Pre stages at chromosome 3 (46.5–51.5 Mb). The pink-shaded area indicates the up-regulated gene LRRC2 in the H3K27ac gained region; the blue-shaded area indicates the down-regulated gene SMARCC1 in the H3K27ac lost region. Abbreviations: HSPC, hematopoietic stem and progenitor cell; Ery-Pro, erythroid progenitor; Ery-Pre, erythroid precursor.