Fig. 7.

Intravasation of tumor cells on microfluidic chips: (A) the real picture and the structure of the chip, (B) fluorescent images of the vascular network and (C) permeability of blood vessels after intravasation of breast cancer cells (Reprinted with permission from Ref. [97], Copyright 2018 Wiley); (D) chip structure and (E) confocal images of breast cancer cells intravasated into blood vessels (Reprinted with permission from Ref. [233], Copyright 2022 AIP Publishing); (F) the cell-laden chip and (G) tumor cells derived from glioblastoma patients in the microvasculature (Reprinted with permission from Ref. [236], Creative Commons By 4.0 (https://creativecommons.org/licenses/by/4.0)).