Fig. 2. The production of TIMP-1 from human AECs. The production of TIMP-1 from AECs (SAECs and A549) in response to (A) poly I:C, (B) IL-13, and in coculture with (C) PBEs as well as (D) in response to EETs (n = 6 for each group). Data are presented as mean ± standard deviation.

AECs, airway epithelial cells; A549, type II alveolar epithelial cell line; IL, interleukin; Dex, dexamethasone; EETs, eosinophil extracellular traps; PBEs, peripheral blood eosinophils; SAECs, primary small airway epithelial cells; TIMP-1, tissue inhibitor of metalloproteinase-1.

^***P < 0.001 by one-way analysis of variance with the Bonferroni post hoc test.