Table 9.
Significant Clusters of Whole-Brain Exploratory Analyses.
|
MNI Coordinates |
|||||||
|---|---|---|---|---|---|---|---|
| Cluster size (voxels) | Brain region | Hemisphere | x | y | z | Zmax | |
| Group Comparisons | |||||||
| CUD > CON | |||||||
| 1097 | Paracingulate gyrus, Anterior cingulate gyrus, Frontal medial cortex, frontal pole | L/R | −12 | 40 | 14 | 4.51 | |
| CON > CUD | – | – | – | – | – | – | |
| Group X Site | – | – | – | – | – | – | |
| Association with cannabis measure | |||||||
| Grams/Week | – | – | – | – | – | – | |
| CUD Severity | – | – | – | – | – | – | |
| Site X Covariate Interactions | |||||||
| NL > TX | |||||||
| Grams/Week | – | – | – | – | – | – | |
| CUD Severity | – | – | – | – | – | – | |
| TX > NL | |||||||
| Grams/Week | 388 | Putamen, Amygdala, Hippocampus, Insula | L | −28 | −6 | 8 | 3.82 |
| CUD Severity | – | – | – | – | – | – | |
Note. Results of whole-brain analysis with cluster-wise correction of Z = 2.3, p <.05. CUD = Cannabis Use Disorder group; CON = non-cannabis-using controls; TX = Texas; NL = The Netherlands; CUD > CON cluster no longer significant when controlling for group differences in gender.