Table 3.

Example reference regimen (DA EPOCH-R) codified and aligned to the reference library database for dose level 1*

Row	INN of drug	Dose quantity	Dose unit	Route of admin	Cycle numbers	Cycle durations (days)	Cycle admin day numbers	Cycle admin frequency per day
1	Prednisolone	60	mg/m2	Oral	1,2,3,4,5,6	21,21,21,21,21,21	1–5,1–5,1–5,1–5,1–5,1–5	2,2,2,2,2,2
2	Rituximab	375	mg/m2	Intravenous	1,2,3,4,5,6	21,21,21,21,21,21	1,1,1,1,1,1	1,1,1,1,1,1
3	Doxorubicin	10	mg/m2	Continuous Intravenous	1,2,3,4,5,6	21,21,21,21,21,21	1–4,1–4,1–4,1–4,1–4,1–4	1,1,1,1,1,1
4	Vincristine	0,4	mg/m2	Continuous Intravenous	1,2,3,4,5,6	21,21,21,21,21,21	1–4,1–4,1–4,1–4,1–4,1–4	1,1,1,1,1,1
5	Etoposide	50	mg/m2	Continuous Intravenous	1,2,3,4,5,6	21,21,21,21,21,21	1–4,1-4,1–4,1-4,1–4,1-4	1,1,1,1,1,1
6	Cyclophosphamide	750	mg/m2	Intravenous	1,2,3,4,5,6	21,21,21,21,21,21	5,5,5,5,5,5	1,1,1,1,1,1

*Subsequent cycles will be recognisable in a clinical anonymised database, based on the fact that each patient starts at dose level 1.

INN, International non-proprietary name.