Table 2.

Genotypic and haplotypic linkage of CYP1A1 rs4646903 and rs1048943 polymorphisms with cervical cancer.

SNPs	Model	Genotype/Allele	Case (%)	Control (%)	Crude analysis		Statistical Power (%)
					OR (95% Cl)	p-value
rs4646903		TT	99 (53.51%)	166 (75.45%)	1		93.4
	Additive model 1 (TC vs. TT)	TC	69 (37.30%)	48 (21.82%)	2.41 (1.55–3.76)	0.0001
	Additive model 2 (CC vs. TT)	CC	17 (9.19%)	6 (2.73%)	4.75 (1.81–12.45)	0.002
	Dominant model (TC + CC vs. TT)	TT	99 (53.51%)	166 (75.45%)	1
		TC + CC	86 (46.49%)	54 (24.55%)	2.67 (1.75–4.07)	<0.0001
	Recessive model (CC vs. TT + TC)	TT + TC	168 (90.81%)	214 (97.27%)	1
		CC	17 (9.19%)	6 (2.73%)	3.61 (1.39–9.35)	0.008
	Over-dominant model (TC vs TT + CC)	TT + CC	116 (62.70%)	172 (78.18)	1
		TC	69 (37.30%)	48 (21.82%)	2.13 (1.38–3.30)	0.0007
	Allele	T	267 (72.16%)	380 (86.36%)	1
		C	103 (27.84%)	60 (13.64%)	2.44 (1.71–3.48)	<0.0001
rs1048943		AA	138 (74.59%)	174 (79.09%)	1
	Additive model 1 (AG vs. AA)	AG	40 (21.62%)	40 (18.18%)	1.26 (0.77–2.06)	0.356
	Additive model 2 (GG vs. AA)	GG	7 (3.78%)	6 (2.73%)	1.47 (0.48–4.48)	0.497
	Dominant model (AG + GG vs. AA)	AA	138 (74.59%)	174 (79.09%)	1
		AG + GG	47 (25.41%)	46 (20.91%)	1.29 (0.81–2.05)	0.285	22
	Recessive model (GG vs. AA + AG)	AA + AG	178 (96.22%)	214 (97.27%)	1
		GG	7 (3.78%)	6 (2.73%)	1.40 (0.46–4.25)	0.550
	Over-dominant model (AG vs AA + GG)	AA + GG	145 (78.38%)	120 (54.55%)	1
		AG	40 (21.62%)	40 (18.18%)	0.83 (0.50–1.37)	0.459
	Allele	A	316 (85.41%)	388 (88.18%)	1
		G	54 (14.59%)	52 (11.82%)	1.28 (0.85–1.92)	0.244
rs4646903 and rs1048943	Haplotypes	χ2	Cases	Controls	OR (95% CI)	p-value
	AC	30.61	0.137	0.031	4.86 (2.65–8.94)	9.47x10−8
	AT	21.60	0.716	0.85	0.45 (0.32–0.63)	6.72x10−6
	GC	2.45	0.14	0.104	1.4 (0.92–2.14)	0.117

*Bold values indicate statistically significant (p < 0.05).