Table 2. Cochrane collaboration's tool for assessing the risk of bias.

Bias Domain	Source of Bias	EXPLORER Trial	LUNAR Trial	BLISS 52 Trial	BLISS 76 Trial	BLISS SC Trial	EMBRACE Trial	BLISS LN Trial	CALIBRATE Trial	YOSHIKA et al.	ZHANG et al.
Selection Bias	Random Sequence Generation	+	+	+	+	+	+	+	+	+	+
	Allocation Concealment	+	+	+	+	+	+	+	+	+	+
Performance Bias	Blinding of participants and personnel	+	+	+	+	+	+	+	OPEN LABEL	+	+
Detection Bias	Blinding of outcome assessment	+	+	+	+	+	+	+	+	+	+
Attrition Bias	Incomplete outcome data	+	+	+	+	+	+	+	+	+	+
Reporting Bias	Selective reporting	+	+	+	+	+	+	+	+	+	+
Other Bias	Anything else, ideally prespecified	+	+	+	+	+	+	+	+	+	+