KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| Mouse anti-Hopx | Santa Cruz | Cat#: sc-398703; RRID: AB_2687966 |
| Rabbit anti-SFTPC | Abcam | Cat#: ab90716; RRID: AB_10674024 |
| Chicken anti-GFP | Aves Labs | Cat#: GFP-1020; RRID: AB_10000240 |
| Rabbit anti-RFP | Rockland | Cat#: 600-401-379 AB_ AB_2209751 |
| Rat anti-Ager (Rage) | R&D Systems | Cat#: MAB1179; RRID: AB_2289349 |
| Mouse anti-Ki67 | BD Biosciences | Cat#: 550609; RRID: AB_393778 |
| Rabbit anti-Cldn4 | ThermoFisher | Cat#: 36–4800; RRID: AB_2533262 |
| Mouse Anti- Acta2 | Millipore Sigma | Cat#: A5228; RRID: AB_262054 |
| Rat anti-Lamp3 (DC-Lamp) | Novus | Cat#: DDX0191P-100; RRID: AB_2827532) |
| Mouse anti-Nkx2.1 (TTF1) | Thermo Fisher Scientific | Cat#: MS-699-P1; RRID: AB_142087 |
| Bacterial and virus strains | ||
| H1N1 PR8 | Dr. John E. Wherry’s Lab (University of Pennsylvania) | N/A |
| Chemicals, peptides, and recombinant proteins | ||
| IL-1β | Biolegend | Cat# 575102 |
| SB431542 | Tocris | Cat# 1614 |
| Small Airway Epithelial Cell Growth Medium (SAGM) supplements |
Lonza | Cat# CC-4124 |
| Small airway epithelial cell growth basal media (SABM) | Lonza | Cat# CC-3119 |
| Cholera toxin Millipore | Millipore Sigma | Cat# C9903 |
| EGF | Peprotech | Cat# AF-100-15 |
| Antibiotic-Antimycotic | Gibco | Cat# 15240062 |
| Fetal Bovine Serum | Denville | Cat# FB5001 |
| Matrigel | Corning | Cat# 356231 |
| Slowfade Diamond Antifade Mountant | Invitrogen | Cat# S36972 |
| Deposited data | ||
| RNA-seq at 14dpi | This paper | GEO: GSE |
| Critical commercial assays | ||
| PureLink RNA Mini Kit | Invitrogen | Cat# 12183-016 |
| NEBNext Single Cell/Low Input RNA Library Prep Kit for Illumina |
New England Biolabs | Cat# E6420 |
| Click-iT EdU cell proliferation kit | Invitrogen | Cat #C10634) |
| Experimental models: Organisms/strains | ||
| R26REYFP | Jackson Laboratory | stock # 007903 |
| R26RtdTomato | Jackson Laboratory | stock # 007914 |
| Tfcp2l1CreERT2 | Jackson Laboratories | stock # 028732 |
| SftpcCreERT2 | PMCID: PMC3223845 | N/A |
| Tfcp2l1flox | PMCID: PMC5484618 | N/A |
| Software and algorithms | ||
| LungDamage program | PMID: 33979629 | https://github.com/WALIII/LungDamage |
| Graphpad Prism9 | GraphPad | https://www.graphpad.com/scientific-software/prism/ |
| Illustrator | Adobe | https://www.adobe.com/products/illustrator.html |
| MATLAB | MathWorks | https://www.mathworks.com/products/matlab.html |
| Fiji | PMID: 22743772 | https://fiji.sc/R 4.0.5 |
| R 4.0.5 | R Project | https://www.r-project.org/ |
| FlowJo 10.7.1 | PMCID: PMC5484618 | N/A |