Figure 3 –

Zafirlukast and montelukast selectively cause cancer cell cytotoxicity. (A) Zafirlukast is about 5x more cytotoxic than montelukast and 1.5× more cytotoxic than the analogue (n=3). (B) Comparison of the relative potency of each compound in the experiments from Figure 1, Figure 2 and Figure 3A. (C) Zafirlukast also induced cytotoxicity to HCT116 colon tumor cells, PC3 prostate cancer cells, and A549 lung cancer cells selectively over the HEK293 non-cancerous cell line (n=3).