Table 3.

Longitudinal slope showing the annual change (over 3 years) in imaging and clinical parameters

Metric	Mean	SD	Δ from baseline	SRM	P-value
					Raw	Corrected
Morphometry—FreeSurfer
Medulla	−0.000013	0.000047	−0.5%	−0.28	0.109	0.218
Pons	−0.000053	0.000087	−0.7%	−0.60	0.006	0.035
Midbrain	−0.000025	0.000041	−0.7%	−0.60	0.006	0.030
Thalamus	−0.000175	0.000211	−1.9%	−0.83	5.61 × 10 − 4	0.004
Fourth ventricle	0.000065	0.000076	3.9%	0.86	4.21 × 10−4	0.004
SCP	−0.000002	0.000006	−2.1%	−0.40	0.041	0.165
CSF	0.000017	0.000057	1.3%	0.30	0.091	0.272
VentralDC	−0.000046	0.000055	−0.9%	−0.85	4.65 × 10−4	0.004
CC mid-posterior	0.000003	0.000019	1.4%	0.17	0.218	0.218
Morphometry—CERES
Cerebellum WM	−0.000083	0.000074	−1.0%	−1.12	2.53 × 10−5	7.58 × 10−5
Cerebellum	−0.000572	0.000517	−0.7%	−1.11	2.87 × 10−5	5.73 × 10−5
Cerebellum GM	−0.000490	0.000481	−0.7%	−1.02	7.43 × 10−5	7.43 × 10−5
DTI—FA
SCP	−0.007770	0.013606	−1.7%	−0.57	0.010	0.049
ICP	−0.000680	0.019265	−0.2%	−0.04	0.438	0.876
PLIC	−0.000784	0.003736	−0.1%	−0.21	0.180	0.720
SCR	0.000049	0.004100	0.0%	0.01	0.479	0.479
Fx_ST	−0.001470	0.008479	−0.3%	−0.17	0.224	0.671
DTI—RD
SCP	0.000021	0.000022	2.7%	0.97	1.83 × 10−4	9.13 × 10−5
ICP	0.000045	0.000074	4.7%	0.61	0.007	0.028
PLIC	−0.000001	0.000004	−0.2%	−0.19	0.202	0.606
SCR	−0.000001	0.000004	−0.1%	−0.13	0.284	0.567
Fx_ST	0.000001	0.000011	0.2%	0.07	0.373	0.373
FBA—FD
SCP	−0.014312	0.025843	−1.9%	−0.55	0.011	0.023
ICP	0.005337	0.041857	0.8%	0.13	0.288	0.288
PLIC	−0.006910	0.011755	−0.7%	−0.59	0.008	0.025
SCR	−0.006384	0.007644	−0.8%	−0.84	0.001	0.003
FBA—FC
SCP	−0.017919	0.021921		−0.82	0.001	0.002
ICP	−0.009043	0.018887		−0.48	0.023	0.023
PLIC	−0.015104	0.012951		−1.17	2.46 × 10−5	9.84 × 10−5
SCR	−0.019465	0.021621		−0.90	3.61 × 10−4	0.001
FBA—FDC
SCP	−0.026530	0.025556	−3.7%	−1.04	8.88 × 10−5	3.55 × 10−4
ICP	−0.000328	0.035886	−0.1%	−0.01	0.484	0.484
PLIC	−0.021052	0.021666	−2.3%	−0.97	1.21 × 10−4	3.62 × 10−4
SCR	−0.021441	0.021275	−2.9%	−1.01	1.74 × 10−4	3.48 × 10−4
Clinical
ADL	1.954783	1.324931	26%	1.48	7.07 × 10−7	3.53 × 10−6
FARS total neuro	4.930495	4.244949	10%	1.16	1.64 × 10−5	6.58 × 10−5
SARA	2.068959	1.809986	17%	1.14	1.17 × 10−4	2.35 × 10−4
Functional staging	0.330311	0.328952	14%	1.00	8.64 × 10−5	2.59 × 10−4
9HPT non-dominant	2.953038	4.731900	6%	0.62	0.005	0.005

Volumes are normalized by total intracranial volume. Bold values are significant P-values.