Table 1.
Baseline Characteristics
| All Patients (n = 42) |
IV Administration (n = 28) |
SC Administration (n = 14) |
P-value | |
|---|---|---|---|---|
| Female Sex, n (%) | 24 (57) | 15 (54) | 9 (64) | 0.51 |
| Age (y), median (IQR) | 32.5 (22.3, 62.3) | 29.5 (22.0, 60.0) | 37.5 (23.8, 64.8) | 0.85 |
| Disease severity, n (%) | ||||
| SAA | 38 (90) | 25 (89) | 13 (93) | 1.0 |
| VSAA | 4 (10) | 3 (11) | 1 (7) | |
| Number of Prior Immunosuppressive Treatments, n (%) | ||||
| One | 31 (74) | 23 (82) | 8 (57) | 0.75 |
| Two | 9 (21) | 6 (21) | 3 (21) | |
| Three | 1 (2) | 1 (4) | 0 | |
| Four | 0 | 0 | 0 | |
| Five | 1 (2) | 0 | 1 (7) | |
| Laboratory Values, median (IQR) | ||||
| Hemoglobin (g/dL) | 8.8 (8.4, 9.2) | 8.8 (8.4, 9.2) | 8.8 (7.7, 9.2) | 0.93 |
| Platelets (x109/L) | 28.0 (17.3, 43.0) | 31.5 (19.5, 42.3) | 23.0 (10.8, 44.5) | 0.45 |
| Absolute Neutrophil Count (x109/L) | 0.8 (0.4, 1.3) | 0.7 (0.4, 1.2) | 0.8 (0.4, 1.5) | 0.62 |
| Absolute Lymphocyte Count (x109/L) | 0.2 (0.1, 0.4) | 0.2 (0.1, 0.5) | 0.3 (0.1, 0.4) | 1 |
| Absolute Reticulocyte Count (x109/L) | 29.9 (14.0, 46.8) | 30.6 (15.9, 43.7) | 21.8 (12.0, 46.8) | 0.87 |
| PNH Clone, n (%) | 19 (45) | 10 (36) | 9 (64) | 0.18 |
Abbreviations: IQR = interquartile range; IV = intravenous; PNH = paroxysmal nocturnal hemoglobinuria; SAA = severe aplastic anemia; SC = subcutaneous; VSAA = very severe aplastic anemia