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. 2023 Jul 3;145(28):15171–15179. doi: 10.1021/jacs.3c01902

Figure 1.

Figure 1

(A) Chemical structure of amphiphilic xenopeptides for Cas9 RNP delivery. “Stp number” indicates the number of ionizable Stp building units at each side of the lysine. (B) eGFP knockout efficiency and cell viability of HeLa eGFP/tub cells after 48 h treatment with Cas9 RNP nanocarriers at 75 nM RNP dose. Fatty acid residues are indicated by color code. (C) eGFP knockout efficiency of HeLa eGFP/tub cells after 48 h treatment with Cas9 RNP nanocarriers at a series of RNP concentrations ranging from 1 nM to 100 nM. Data are presented as mean ± SD (n = 3).