Table 4. Process Conditions Applied to the gPROMS/PharmaMV Digital Twin for Supersaturation MPC Performance Testing.
crystallizer volume (mL) | 500 |
D50 of seed CSD (μm) | 110 |
standard deviation of seed CSD (μm) | 25 |
initial seed mass (g) | 1 |
initial temperature (°C) | 40 |
end temperature (°C) | 5 |
supersaturation set-point | 0.012, 0.024, 0.036 |