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. 2023 Jul 3;62(28):11067–11081. doi: 10.1021/acs.iecr.3c00371

Table 4. Process Conditions Applied to the gPROMS/PharmaMV Digital Twin for Supersaturation MPC Performance Testing.

crystallizer volume (mL) 500
D50 of seed CSD (μm) 110
standard deviation of seed CSD (μm) 25
initial seed mass (g) 1
initial temperature (°C) 40
end temperature (°C) 5
supersaturation set-point 0.012, 0.024, 0.036