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Time–activity curves representing the concentration of radioactivity in the NHP brain (A) at baseline and (B) after pretreatment with thiamet-G and unchanged [11C]BIO-1819578 in plasma (C) after intravenous injection of [11C]BIO-1819578 into a non-human primate. The plasma curve represents the radiometabolite-corrected arterial input function.
