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| precursor (mg) | alkylating agent | solvent | Temp (°C) | RCC (%) |
|---|---|---|---|---|
| 1.0 | CH3I | THF | RT and 100 | 0 |
| 2.0 | 60 and 120 | <1 | ||
| 5.0 | 60 and 120 | <1 | ||
| 2.0 | CH3I | DMF | RT and 100 | <1 |
| 2.0 | CH3I | DMSO | 100 | 0 |
| 2.0 | CH3I | acetonitrile | RT and 80 | 0 |
| 1.0 | CH3I | dioxan | 120 | 0 |
| 2.0 | 120 | <1 | ||
| 1.0 | (COD)PdMeCl | THF | 80 | >20 |
| 100 | >25 | |||
| 2.0 | (COD)PdMeCl | THF | 110 | >55 |
| 2.0 | (COD)PdMeCl | THF | 135 | >50 |
| 5.0 | (COD)PdMeCl | THF | 110 | >55 |
| 2.0 | (COD)PdMeCl | dioxan | 110 | >55 |
| 5.0 | (COD)PdMeCl | dioxan | 110 | >50 |
