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. Author manuscript; available in PMC: 2023 Nov 21.
Published in final edited form as: Nanoscale Horiz. 2022 Nov 21;7(12):1540–1552. doi: 10.1039/d2nh00331g

Figure 1. SERS nanoparticle library based on 8 commercially available IR dyes and 20 ChPIR dyes as Raman reporters.

Figure 1

(a) Raman reporters are ordered by chemical similarity for a systematic approach to developing a SERS nanoparticle library, forming four classes with related signal intensity and complexity. (b) SERS nanoparticles synthesized with the 28 reporters and imaged in a standard plastic 1536-well plate at various concentrations. Compounds grouped by chemical similarity demonstrate similar spectral features and intensities. (c) Each nanoparticle type provides a uniquely identifiable spectrum, shown here after baseline subtraction and averaging of 98 point spectra. (d) Peak signal intensity for each of the 22 brightest nanoparticles at various concentrations shows the dynamic range of the SERS signal.