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. 2023 Mar 15;18(11):2489–2496. doi: 10.4103/1673-5374.371399

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Cytosine methylation is dynamic and abundant in CG and non-CG contexts during spinal cord injury in mice.

(A) Percentage of methylated base calls throughout the genome in CpG, CHG, and CHH contexts at indicated time points after injury. The raw data obtained from the Bismark tool were uploaded in Additional Table 2. (B) The percentage of total methylated cytosine was significantly reduced in SCI samples compared with sham samples; methylation mostly included mCH events (mean ± SD, Student’s t-test, *P < 0.05, vs. sham group). (C) The methylation levels of CpG, CHG, and CHH fluctuate over time (mean ± SD, one-way analysis of variance followed by Bonferroni correction, *P < 0.05, **P < 0.01, ***P < 0.01, vs. sham group). mC: Methylated cytosine.