Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 15;18(11):2489–2496. doi: 10.4103/1673-5374.371399

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Neural Regeneration Research

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

PMC Copyright notice

Landscape of DNA methylation across the whole genome.

(A) Heatmap of 26,816 mouse genes organized in gene sets identified by k-means clustering in CpG, CHG, and CHH contexts at the indicated phases. The dataset of methylation levels was calculated with the SeqMonk software with RRBS pipeline. The raw methylation levels were processed with log transform. The ComplexHeatmap R package (k-mean = 5) was used to generate the heatmap. Legends for CpG, CHG and CHH methylation levels are on the bottom of the heatmaps. (B) Overview of CpG, CHG and CHH methylation at genic regions, including the promoter, 5′UTR, exon, intron and 3′UTR. The genomic annotation was downloaded from the USCS genome browser and then imported into the SeqMonk software. The quantitation trend plot function was applied to compare the methylation levels within the genomic elements. mCG: Methylated CG dinucleotide; mCHG: methylated CHG trinucleotide; mCHH: methylated CHH trinucleotide; PC: principal component; UTR: untranslated region.