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. 2023 Mar 15;18(11):2489–2496. doi: 10.4103/1673-5374.371399

Figure 5.

Figure 5

GO and KEGG analysis for temporal methylation changes of promoter DMGs in the CpG context.

GO terms and KEGG of 16 promoter DMR modules and their averaged temporal methylation changes post-SCI. The most significant MF (red font), CC (green font), BP (blue font), and KEGG (black font) are presented. In the GO and KEGG analysis, the differential methylated gene list was constructed with the clusterProfiler R package. The adjusted P value method was controlled by the Benjamini-Hochberg (BH) algorithm. For CpG context, P < 0.01 was set as cutoff; P < 0.05 was set as the cutoff for CH contexts. The GO/KEGG temporal plots of DMRs were generated with mfuzz R package. BP: Biological process; CC: cell component; E.: early; GO: Gene Ontology; I.m.: intermediate; KEGG: Kyoto Encyclopedia of Genes and Genomes; L.: late; MF: molecular function; S.: Sham.