Figure 6.

Correlation between DNA methylation and gene transcription in spinal cord injury.

(A) The Pearson correlation between CpG and non-CpG methylation levels and relative gene transcription profile in spinal cord injury. The red line indicates the best fit through the data of two variables. The RNA-Seq dataset of the same mouse spinal cord injury model (T9 crush injury) was downloaded from our previous study (Li et al., 2022). (B) The global heatmap of corresponding gene transcription and DNA methylation during spinal cord injury. The transcription levels are represented by FPKM from RNA-Seq and corresponding clusterProfiler R package. The k-mean was set as 6 and indicated by the number in the RNA-Seq blocks. DMR: Differentially methylated regions. FPKM: fragments per kilobase per mapped read; RNA-Seq: RNA sequencing.