The amount, distribution and context of methylated cytosine through the whole genome after spinal cord injury | ||||||||||||||
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Total C’s analysed | mC in CpG | mC in CHG | mC in CHH | mC in CH | total mC | UmCin CpG | total CpG | UmCin CHG | total CHG | UmCin CHH | total CHH | UmCin CH | Total CH | |
shamJL | 842,429,538 | 54,994,269 | 2,315,844 | 5,327,073 | 7,642,917 | 62,637,186 | 62,114,492 | 117,108,761 | 212,906,623 | 215,222,467 | 504,771,237 | 510,098,310 | 932,900,327 | 940,543,244 |
sham_2 | 685,890,086 | 44,962,151 | 1,759,987 | 4,022,632 | 5,782,619 | 50,744,770 | 53,746,413 | 98,708,564 | 173,979,806 | 175,739,793 | 407,419,097 | 411,441,729 | 757,138,696 | 762,921,315 |
sham_3 | 669,216,659 | 43,981,658 | 1,750,129 | 3,991,321 | 5,741,450 | 49,723,108 | 52,503,230 | 96,484,888 | 170,074,956 | 171,825,085 | 396,915,365 | 400,906,686 | 738,815,406 | 744,556,856 |
D0_1 | 740,058,636 | 47,277,785 | 1,938,121 | 4,514,325 | 6,452,446 | 53,730,231 | 53,951,243 | 101,229,028 | 185,587,957 | 187,526,078 | 446,789,205 | 451,303,530 | 819,903,240 | 826,355,686 |
D0_2 | 802,397,693 | 52,113,439 | 1,933,781 | 4,185,911 | 6,119,692 | 58,233,131 | 61,963,626 | 114,077,065 | 202,970,595 | 204,904,376 | 479,230,341 | 483,416,252 | 887,105,312 | 893,225,004 |
D0_3 | 835,534,708 | 54,163,266 | 1,998,758 | 5,012,725 | 7,011,483 | 61,174,749 | 55,864,246 | 110,027,512 | 203,860,943 | 205,859,701 | 514,634,770 | 519,647,495 | 924,355,414 | 931,366,897 |
Dl_l | 563,865,388 | 35,026,270 | 1,226,164 | 2,950,892 | 4,177,056 | 39,203,326 | 39,677,439 | 74,703,709 | 138,783,034 | 140,009,198 | 346,201,589 | 349,152,481 | 624,993,821 | 629,170,877 |
Dl_2 | 794,989,317 | 51,221,832 | 1,872,044 | 4,300,220 | 6,172,264 | 57,394,096 | 63,158,771 | 114,380,603 | 200,480,716 | 202,352,760 | 473,955,734 | 478,255,954 | 876,789,210 | 882,961,474 |
Dl_3 | 601,484,603 | 38,846,925 | 1,223,920 | 2,694,908 | 3,918,828 | 42,765,753 | 41,142,248 | 79,989,173 | 149,698,141 | 150,922,061 | 367,878,461 | 370,573,369 | 668,498,663 | 672,417,491 |
D3_1 | 640,373,041 | 38,862,774 | 1,449,369 | 3,524,905 | 4,974,274 | 43,837,048 | 44,855,608 | 83,718,382 | 155,881,890 | 157,331,259 | 395,798,495 | 399,323,400 | 709,011,644 | 713,985,918 |
D3_2 | 734,842,848 | 45,495,979 | 1,781,328 | 4,453,384 | 6,234,712 | 51,730,691 | 52,298,130 | 97,794,109 | 180,014,308 | 181,795,636 | 450,799,719 | 455,253,103 | 812,609,663 | 818,844,375 |
D3_3 | 648,080,110 | 39,056,626 | 1,571,599 | 3,943,381 | 5,514,980 | 44,571,606 | 42,946,654 | 82,003,280 | 155,793,028 | 157,364,627 | 404,768,822 | 408,712,203 | 717,926,477 | 723,441,457 |
D7_1 | 724,092,220 | 44,860,645 | 1,628,173 | 3,412,579 | 5,040,752 | 49,901,397 | 53,097,892 | 97,958,537 | 182,199,685 | 183,827,858 | 438,893,246 | 442,305,825 | 804,920,789 | 809,961,541 |
D7_2 | 801,026,750 | 50,036,177 | 1,922,069 | 4,415,089 | 6,337,158 | 56,373,335 | 58,618,021 | 108,654,198 | 201,139,911 | 203,061,980 | 484,895,483 | 489,310,572 | 889,097,374 | 895,434,532 |
D7_3 | 887,027,971 | 55,145,861 | 1,759,801 | 3,811,845 | 5,571,646 | 60,717,507 | 65,068,186 | 120,214,047 | 223,856,907 | 225,616,708 | 537,385,371 | 541,197,216 | 986,858,986 | 992,430,632 |
D14_1 | 773,197,615 | 48,273,723 | 1,699,005 | 3,692,856 | 5,391,861 | 53,665,584 | 56,125,486 | 104,399,209 | 194,099,024 | 195,798,029 | 469,307,521 | 473,000,377 | 859,204,574 | 864,596,435 |
D14_2 | 751,529,174 | 45,467,695 | 1,428,734 | 3,140,148 | 4,568,882 | 50,036,577 | 54,811,715 | 100,279,410 | 187,318,211 | 188,746,945 | 459,362,671 | 462,502,819 | 835,427,827 | 839,996,709 |
D14_3 | 747,812,397 | 46,854,334 | 1,351,166 | 2,781,215 | 4,132,381 | 50,986,715 | 53,083,298 | 99,937,632 | 187,142,974 | 188,494,140 | 456,599,410 | 459,380,625 | 832,236,524 | 836,368,905 |
D28_1 | 865,031,656 | 53,965,853 | 2,050,638 | 4,973,766 | 7,024,404 | 60,990,257 | 62,481,622 | 116,447,475 | 216,014,310 | 218,064,948 | 525,545,467 | 530,519,233 | 959,624,725 | 966,649,129 |
D28_2 | 488,369,842 | 34,534,302 | 1,086,728 | 2,383,188 | 3,469,916 | 38,004,218 | 38,804,015 | 73,338,317 | 129,367,352 | 130,454,080 | 282,194,257 | 284,577,445 | 542,015,689 | 545,485,605 |
D28_3 | 711,340,972 | 44,133,614 | 1,631,822 | 3,757,447 | 5,389,269 | 49,522,883 | 53,942,098 | 98,075,712 | 178,506,315 | 180,138,137 | 429,369,676 | 433,127,123 | 788,014,128 | 793,403,397 |
D42_1 | 671,358,301 | 43,970,734 | 1,675,276 | 3,756,497 | 5,431,773 | 49,402,507 | 52,439,086 | 96,409,820 | 171,676,005 | 173,351,281 | 397,840,703 | 401,597,200 | 742,867,989 | 748,299,762 |
D42_2 | 730,293,196 | 47,608,062 | 1,786,388 | 3,945,949 | 5,732,337 | 53,340,399 | 54,943,465 | 102,551,527 | 185,879,442 | 187,665,830 | 436,129,890 | 440,075,839 | 809,675,162 | 815,407,499 |
D42_3 | 808,504,576 | 51,206,979 | 1,872,886 | 4,157,761 | 6,030,647 | 57,237,626 | 60,272,331 | 111,479,310 | 203,208,145 | 205,081,031 | 487,786,474 | 491,944,235 | 896,075,650 | 902,106,297 |
Max | 887,027,971 | 55,145,861 | 2,315,844 | 5,327,073 | 7,642,917 | 62,637,186 | 65,068,186 | 120,214,047 | 223,856,907 | 225,616,708 | 537,385,371 | 541,197,216 | 986,858,986 | 992,430,632 |
Sham | 2,197,536,283 | 143,938,078 | 5,825,960 | 13,341,026 | 19,166,986 | 163,105,064 | 168,364,135 | 556,961,385 | 1,309,105,699 | 1,866,067,084 | 1,885,234,070 | |||
DO | 2,377,991,037 | 153,554,490 | 5,870,660 | 13,712,961 | 19,583,621 | 173,138,111 | 171,779,115 | 592,419,495 | 1,440,654,316 | 2,033,073,811 | 2,052,657,432 | |||
D1 | 1,960,339,308 | 125,095,027 | 4,322,128 | 9,946,020 | 14,268,148 | 139,363,175 | 143,978,458 | 488,961,891 | 1,188,035,784 | 1,676,997,675 | 1,691,265,823 | |||
D3 | 1,976,700,492 | 123,205,678 | 4,454,617 | 10,673,197 | 15,127,814 | 138,333,492 | 138,295,986 | 485,594,339 | 1,214,476,675 | 1,700,071,014 | 1,715,198,828 | |||
D7 | 2,412,146,941 | 150,042,683 | 5,310,043 | 11,639,513 | 16,949,556 | 166,992,239 | 176,784,099 | 607,196,503 | 1,461,174,100 | 2,068,370,603 | 2,085,320,159 | |||
D14 | 2,272,539,186 | 140,595,752 | 4,478,905 | 9,614,219 | 14,093,124 | 154,688,876 | 164,020,499 | 568,560,209 | 1,385,269,602 | 1,953,829,811 | 1,967,922,935 | |||
D28 | 2,064,742,470 | 132,633,769 | 4,769,188 | 11,114,401 | 15,883,589 | 148,517,358 | 155,227,735 | 523,887,977 | 1,237,109,400 | 1,760,997,377 | 1,776,880,966 | |||
D42 | 2,210,156,073 | 142,785,775 | 5,334,550 | 11,860,207 | 17,194,757 | 159,980,532 | 167,654,882 | 560,763,592 | 1,321,757,067 | 1,882,520,659 | 1,899,715,416 |