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. 2023 Mar 15;18(11):2449–2458. doi: 10.4103/1673-5374.371370

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Sirt6 overexpression improves functional connectivity damaged by chronic sleep deprivation.

(A) CSD + eGFP versus Con + eGFP groups; (B) CSD + Sirt6 versus CSD + eGFP groups. The colored bar in the image presents the t-values of the comparisons (P < 0.05). 5Cb: 5^th cerebellar lobule; 6Cb: 6^th cerebellar lobule; AI: agranular insular cortex; AO: anterior olfactory nucleus; Crus 1 & 2: crus 1 & 2 of the ansiform lobule; CSD: chronic sleep deprivation; eGFP: enhanced green fluorescent protein; FrA: frontal cortex; M1: primary motor cortex; PrL: prelimbic cortex; S1: primary somatosensory cortex 1; Sirt6: Sirtuins 6.